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Anti-Methylglyoxal Mouse Antibody
Methylglyoxal, 2-Oxopropanal, 2 oxo propanal, MG, Pyruvaldehyde, Methylglyoxal (MG), MG-modified protein
As low as
$804.00
In stock
Ref
00123907
Lipid peroxidation occurs when oxidizing agents attack carbon-carbon double bonds found in unsaturated lipids. In addition to membrane degradation, oxidation end-products have been found to damage cell viability through their mutagenic and toxic properties. These downstream functional consequences facilitate the development of disease and premature aging. Methylglyoxal is an alpha-oxoaldehyde generated from lipid peroxidation that reacts with proteins to form adducts(1). It reacts with free amino acids and protein residues to generate advanced glycation endproducts (AGEs) and crosslinks DNA polymerase and substrate DNA to severely inhibit DNA replication (2).
| ID Covalab | mab60830 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 9E7 |
| Isotype | IgG2a |
| Raised in | Mouse |
| Immunogen | Synthetic Methylglyoxal modified Keyhole Limpet Hemocyanin (KLH). |
| Activity cross reaction | Specific for Methylglyoxal modified proteins. Does not detect free Methylglyoxal. Does not cross-react with Acrolein, Hexanoyl Lysine, Malondialdeyhde, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, or Crotonaldehyde modified proteins. |
| Species | Species Independent |
| Form | Purified |
| Preservative | 0.09% Sodium azide |
| Storage instructions | This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | Methylglyoxal |
| Applications | ELISA, FACS, FCM, ICC/IF, WB |
| Working dilutions | WB (1:1000); ICC/IF (1:50); FACS (1:50); FCM (1:50); ELISA (1:1000); IHC (1:50); optimal dilutions for assays should be determined by the user. |
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