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Anti-Estrogen Receptor beta Antibody
ER-beta, Nuclear receptor subfamily 3 group A member 2
As low as
$734.00
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00123639
Anti-Estrogen Receptor beta Antibody
ID Covalab | mab60674 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | 6A12 |
Isotype | IgG2b |
Raised in | Mouse |
Immunogen | 6-His fusion protein containing the region encoding aa 1-153 of human estrogen receptor-b (ER-b) expressed in E. coli. |
Activity cross reaction | This antibody recognizes human ER-b, a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER-b are very similar to ER-alpha with the ligand and DNA binding domains being highly conserved. The N-terminus of each receptor, which serves as their transactivation domain, are significantly different. Like ER-alpha, ER-b binds to estrogen with a high affinity and regulates estrogen-specific gene activation through direct interaction with estrogen response elements. |
Species | Human |
Form | Purified |
Storage instructions | This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze- thaw cycles. |
Target | Estrogen Receptor beta |
Uniprot ID | Q92731 |
Gene ID | 2100 |
Applications | ChIP, ICC/IF, IHC, WB |
Working dilutions | Immunoblotting: use at 1-5 ug/mL. Positive controls: Native receptor from human thymus, spleen, ovary, and testis or recombinant protein. |
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