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Anti-BRCA1 Antibody
EC 2.3.2.27, RING finger protein 53, RING-type E3 ubiquitin transferase BRCA1
As low as
$734.00
In stock
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00123636
Anti-BRCA1 Antibody
| ID Covalab | mab60671 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 3A2 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | GST fusion protein expressed in E. coli corresponding to aa 762-1315 of full-length BRCA1. |
| Activity cross reaction | This antibody recognizes full-length BRCA1, a 220 kD nuclear phosphoprotein, and does not recognize the deltaexon 11 splice variant. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness to monitor functional inactivation of BRCA1 in sporadic breast cancers is under active investigation. |
| Species | Human |
| Form | Purified |
| Storage instructions | This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze-thaw cycles. |
| Target | BRCA1 |
| Uniprot ID | P38398 |
| Gene ID | 672 |
| Applications | IHC, IHC-P, IP, WB |
| Working dilutions | Immunoblotting: use at 1-10 ug/mL. Immunoprecipitation: use at 1-10 ug/mL. Immunohistochemistry: use at 1-10 ug/mL. Positive controls: Any normal human tissue, especially those containing rapidly proliferating cells, such as lymphoid germinal centers. |
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