GRAP2 antibody (UW40) [APC]

GRB2-related adapter protein 2
Adapter protein GRID
GRB-2-like protein (GRB2L)
GRBLG
GRBX
Grf40 adapter protein (Grf-40)
Growth factor receptor-binding protein
Hematopoietic cell-associated adapter protein GrpL
P38
Protein GADS
SH3-SH2-SH3 adapter Mona
Gene name: GRAP2
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00118928
GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.
More Information
ID Covalab mab21315
Product type Primary antibodies
Clonality Monoclonal antibody
Clone UW40
Isotype IgG2a
Raised in Mouse
Immunogen The mouse monoclonal antibody UW40 recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
Activity cross reaction GST-fusion human GRAP2/GADS protein
Species Hu
Labelling ACE
Form Purified
Preservative NaN3 15 mM
Storage instructions Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Target GRAP2
Uniprot ID O75791
Gene ID 9402
Applications FC
Working dilutions Optimal dilution should be determined by the end user.
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