GRP78 antibody

78 kDa glucose-regulated protein, GRP-78
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein, BiP
Gene name: HSPA5, GRP78
As low as $640.00
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00098928
Categorized as stress response proteins, BiPs play an important role in folding and assembly of nascent proteins and in scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5- nontranslated region of BiP mRNA. BiP IRES activity increases when cells are heat-stressed. GRP78 is also important in maintenance of cell homeostasis and the prevention of apoptosis. Levels of GRP78 protein are reduced in brains of Alzheimer’s disease patients.
More Information
ID Covalab pab50362
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide derived from internal domain of the human Grp78 protein. Within residues 250-300.
Activity cross reaction Reacts with GRP-78 protein from human, mouse, rat, Drosophila, sheep and chicken. Predicted to cross reacts with proteins from Bovine, C elegans, Primate, Zebrafish due to 100% sequence homology.
Species Chick, D. mel., Hu, Ms, Rat, Sh
Labelling None
Form Antigen affinity purified
Preservative NaN3 0.1%
Storage instructions Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target 78 kDa glucose-regulated protein, GRP-78
Uniprot ID P11021
Gene ID 3309
Applications FC, ICC, IF, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
WB (0.5 µg/ml)
FC (1:50)
ICC/ IF (1:50)
Publication * S Moulin et al. Curcumin prevents chronic intermittent hypoxia-induced myocardial injury. June 24, 2020
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