Phospholipase C-zeta-1 (PLC-zeta-1) antibody

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Phosphoinositide phospholipase C-zeta-1
Phospholipase C-zeta-1 (PLC-zeta-1)
Testis-development protein NYD-SP27
Gene name: PLCZ1
As low as $465.00
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The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion.
More Information
ID Covalab pab0367
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide derived from internal part of PLC-zeta-1
Activity cross reaction Reacts with human PLC zeta protein.
No cross reaction
Species Hu
Labelling None
Form Antiserum
Preservative None
Storage instructions Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target Phospholipase C zeta isoform (PLC-zeta-1)
Uniprot ID Q86YW0
Gene ID 89869
Applications ELISA, ICC, IHC, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
WB (1:100 - 1:1000)
ICC (1:50 - 1:1000)
Publication * Rahimizadeh P et al. Mol Reprod Dev. 2019 Nov 17
* Kamali-Dolat Abadi M et al. Cell J. 2016 Fall;18(3):438-45. (WB, Hu)
* Ferrer-Vaquer A et al. J Assist Reprod Genet. 2016 Jun,33(6):747-56. (WB)
* Aarabi M et al. Fertil Steril. 2014 Aug;102(2):440-7.
* Kashir J et al. Fertil Steril. 2013 Jan,99(1):107-17. (ICC, Hu)
* Aarabi M et al. PLoS One. 2012,7(3):e33496. (IHC, ICC / Ms, Hu)
* Kashir J et al. Reprod Biomed Online. 2011 Aug,23(2):263-7. (ICC, Hu)
* Young C et al. Fertil Steril. 2009 May,91(5 Suppl):2230-42.
* Grasa P et al. Hum Reprod. 2008 Nov,23(11):2513-22. (WB)
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