PINK1 antibody

Serine/threonine-protein kinase PINK1, mitochondrial
BRPK
PTEN-induced putative kinase protein 1
Gene name : PINK1
As low as $640.00
In stock
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00096390
PTEN induced putative kinase 1 (Pink1) was first discovered when researching the PTEN signaling pathway, thus Pink1 is also involved in many human cancers.It is found in the mitochondria and its homozygous C-terminus mutation has been implicated in the early development of Parkinson's disease. It protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2.
More Information
ID Covalab pab52761
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen A genomic peptide made to an internal region of the human PINK1 protein (within residues 350-500).
Activity cross reaction Reacts with human and mouse PINK1 protein.
Species Hu, Ms
Labelling None
Form Antigen affinity purified
Preservative NaN3 0.05%
Storage instructions Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target PINK1
Uniprot ID Q9BXM7
Gene ID 65018
Applications ICC, IF, IHC, IHC - P
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF 1:500-1:1000,
IHC 1:100,
IHC-P 1:100
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