Nucleolin antibody

Protein C23
Gene name : NCL
As low as $235.00
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00106860
ucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
More Information
ID Covalab pab0971-P
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide of human Nucleolin
Activity cross reaction Reacts with Nucleolin from human, mouse and chicken. Reacts with all the modified and unmodified forms of nucleolin
Species Chick, Hu, Ms
Labelling None
Form Purified (protein A)
Preservative None
Storage instructions Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target Nucleolin
Uniprot ID P19338
Gene ID 4691
Applications IF, IP, WB
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only:
- WB : 1/500 to 1/2000
- IF: 1/200 to 1/1000
Publication * I Ugrinova et al. Nucleolin Interacts and Co-Localizes with Components of Pre-Catalytic Spliceosome Complexes. Sci, 2019
* Cong R et al. Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription. Nucleic Acids Res. 2012 Oct:40(19):9441-54.
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