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DNA-(apurinic or apyrimidinic site) lyase (APE-1) antibody
APEX nuclease (APEN)
Apurinic-apyrimidinic endonuclease 1 (AP endonuclease 1), (APE-1)
REF-1
Redox factor-1
Gene name: APEX1, APE, APE1, APEX, APX, HAP1, REF1
Apurinic-apyrimidinic endonuclease 1 (AP endonuclease 1), (APE-1)
REF-1
Redox factor-1
Gene name: APEX1, APE, APE1, APEX, APX, HAP1, REF1
As low as
$528.40
In stock
Ref
00024739
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.
| ID Covalab | pab50070 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein |
| Activity cross reaction | Reacts with human ~37 kDa APE-1 protein. Cross reacts with proteins from mouse, rat and rabbit. |
| Species | Hu, Ms, Rab, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.05% |
| Storage instructions | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Target | DNA-(apurinic or apyrimidinic site) lyase (APE-1) |
| Uniprot ID | P27695 |
| Gene ID | 328 |
| Applications | B/N, ChIP, ICC, IF, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - IHC: 1/1 000 - WB : 1/1 000 - B/N: 50-200 molar excess - ChIP: 1/10-1/500 - ICC/IF: 1/50-1/200 - IP: 7 µg/ml |
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