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KAT3B/p300 antibody (RW128)
Histone acetyltransferase p300 (p300 HAT)
E1A-associated protein p300
Gene name : EP300, P300
E1A-associated protein p300
Gene name : EP300, P300
As low as
$528.40
In stock
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00030394
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
| ID Covalab | mab50128 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | RW128 |
| Isotype | IgG1 / Kappa |
| Raised in | Mouse |
| Immunogen | Fusion protein containing residues 1572-2371 of human p300 |
| Activity cross reaction | Reacts with human p300 protein (residues 1868-1921). Cross reacts with proteins from mouse, rat, monkey and mink. |
| Species | Hu, Mi, Mk, Ms, Rat |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | NaN3 0.1% |
| Storage instructions | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Target | p300 |
| Uniprot ID | Q09472 |
| Gene ID | 2033 |
| Applications | ICC, IF, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ICC/IF 1:10-1:2000, IP 1:10-1:500, WB 1:250-1:500 |
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