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Hypoxia inducible factor-1 alpha antibody (H1alpha67)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha)
ARNT-interacting protein
Basic-helix-loop-helix-PAS protein MOP1
Class E basic helix-loop-helix protein 78 (bHLHe78)
Member of PAS protein 1
PAS domain-containing protein 8
Gene name: HIF1A, BHLHE78, MOP1, PASD8
ARNT-interacting protein
Basic-helix-loop-helix-PAS protein MOP1
Class E basic helix-loop-helix protein 78 (bHLHe78)
Member of PAS protein 1
PAS domain-containing protein 8
Gene name: HIF1A, BHLHE78, MOP1, PASD8
As low as
$528.40
In stock
Ref
00028903
HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes.
| ID Covalab | mab50049 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | H1alpha67 |
| Isotype | IgG2b |
| Raised in | Mouse |
| Immunogen | Fusion protein containing amino acids 432-528 of human HIF-1alpha |
| Activity cross reaction | Reacts with human HIF-1 alpha. Cross reacts with proteins from monkey, sheep, mouse, rat, rabbit, pig, bovine and ferret. |
| Species | Bov, Ft, Hu, Mk, Ms, Po, Rat, Sh |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | NaN3 0.05% |
| Storage instructions | Store at 4°C. Do not freeze. |
| Target | Hypoxia-inducible factor 1-alpha |
| Uniprot ID | Q16665 |
| Gene ID | 3091 |
| Applications | ChIP, ELISA, FC, GS, ICC, IF, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: IHC 1:100-1:300 WB 1:500-1:1000 ICC/ IF 1:100-1:500 IP 1:10 |
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