Secretory phospholipase A2 receptor (PLA2R) peptide

Secretory phospholipase A2 receptor, PLA2R, PLA2-R
180 kDa secretory phospholipase A2 receptor
C-type lectin domain family 13 member C
M-type receptor
Gene name : PLA2R1, CLEC13C
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Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells.
More Information
ID Covalab pep0527
Product type Peptides
Target domain C-terminal part
Activity cross reaction This peptide blocks completely the immuno reactivity of the antibody pab0527 in WB or IHC by incubating the peptide with equivalent volume of antibody for 30 min at 37 °C.
Species Hu
Labelling None
Antibody / Antigen pab0527
Preservative NaN3 0.02 %
Storage instructions Shipment at 4°C. Upon arrival, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Target PLA2R
Uniprot ID Q13018
Gene ID 22925
Description ELISA, WB, IHC
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