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ATM (2C1) antibody
Serine-protein kinase ATM
Ataxia telangiectasia mutated, A-T mutated
gene name: ATM
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Ataxia telangiectasia mutated, A-T mutated
gene name: ATM
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
As low as
$746.60
In stock
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00096548
ATM is a 370 kD nuclear phosphoprotein,which is involved in the autooal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigations.
| ID Covalab | mab60035 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 2C1 |
| Isotype | IgG1 / Kappa |
| Raised in | Mouse |
| Immunogen | GST fusion protein expressed in E. coli corresponding to aa 2577- 3056 of full-length ATM. |
| Activity cross reaction | Reacts with human ATM. Cross-reacts with mouse, rat and monkey protein. |
| Species | Hu, Mk, Ms, Rat |
| Labelling | None |
| Form | Purified |
| Preservative | None |
| Storage instructions | Stable for at least one year at -20°C or -70°C. Avoid multiple freeze-thaw cycles. |
| Target | ATM |
| Uniprot ID | Q13315 |
| Gene ID | 472 |
| Applications | ChIP, ELISA, FC, ICC, IF, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB 1:500 - 1:3000 IHC-P 5 µg/ml IP 1 - 10 µg/ml. |
| Publication | Chen G, Lee EYHP. The product of the ATM gene is a 370-kDa nuclear phosphoprotein. J Biol Chem. 1996 Dec 27,271(52):33693-7. |
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