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Coagulation factor XIIIa (FXIII) (hu)
Coagulation factor XIII A chain, Coagulation factor XIIIa
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene name: F13A1, F13A
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene name: F13A1, F13A
As low as
$534.82
In stock
Ref
00038966
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
| ID Covalab | opr0034 |
|---|---|
| Uniprot ID | P00488 |
| Target | blood coagulation Factor XIII |
| Storage instructions | Store working aliquots at a minimum of -20°C Avoid repeated freezing and thawing Delivery at ambient temperature is possible |
| Description | Recombinant human Factor XIII is a homodimer (a2) composed of two chains held together by non covalent bonds. After activation of the zymogen by Thrombin and Ca2+ to its active form (a*2, Factor XIIIa), Factor XIIIa catalyzes the formation of covalent bridges (ε-(γ-glutamyl) lysine bonds) between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is insoluble and resistant to lysis. |
| Raised in | Insect cells |
| Species | Hu |
| Form | Recombinant |
| Gene ID | 2162 |
| Poids moléculaire | 83 kDa or 166 kDa |
| Principe | rhFXIIIa catalyzes acyl transfer reactions from glutamine residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue. |
| Pureté | > 95% |
| Product type | Proteins |
| Applications | FA |
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