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CD14 antibody (MOP9)
CD14 antigen
CD14 molecule
Monocyte differentiation antigen CD14
Myeloid cell-specific leucine-rich glycoprotein
My23 antigen
Gene : CD2
CD14 molecule
Monocyte differentiation antigen CD14
Myeloid cell-specific leucine-rich glycoprotein
My23 antigen
Gene : CD2
As low as
$407.00
In stock
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00124713
CD14 recognizes a human monocyte/macrophage antigen of 55 kDa. It reacts with blood monocytes and
has a weak reactivity on blood granulocytes, and interfollicular macrophages. Different cytokines have an
effect on CD14 expression: CD14 expression was studied in dendritic cells generation in vitro. After 5 days
in GMCSF + IL4, CD14 disappears while CD1a expression appears. TNF-alpha skews monocyte differentiation
form macrophages to dendritic cells. The antibody MOP9.25 is used for monocyte depletion before
dendritic cells sorting. (Dimitriu-Bona A., et al, J. Immunol., 1983 ; 130: 145-152 ; Banchereau J. et al,
Annu. Rev. Immunol., 2000; 18: 767-811; Chomarat P. et al, J. Immunol., 2003; 171: 2262-2269).
has a weak reactivity on blood granulocytes, and interfollicular macrophages. Different cytokines have an
effect on CD14 expression: CD14 expression was studied in dendritic cells generation in vitro. After 5 days
in GMCSF + IL4, CD14 disappears while CD1a expression appears. TNF-alpha skews monocyte differentiation
form macrophages to dendritic cells. The antibody MOP9.25 is used for monocyte depletion before
dendritic cells sorting. (Dimitriu-Bona A., et al, J. Immunol., 1983 ; 130: 145-152 ; Banchereau J. et al,
Annu. Rev. Immunol., 2000; 18: 767-811; Chomarat P. et al, J. Immunol., 2003; 171: 2262-2269).
| ID Covalab | mab0288-p |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | MOP9 |
| Isotype | IgG2b kappa |
| Raised in | Mouse |
| Immunogen | Peripheral blood monocytes (patient with rheumatoid arthritis) |
| Species | Human |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed at high levels on monocytes and macrophages, and at lower levels on granulocytes. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. |
| Uniprot ID | P08571 |
| Applications | FC, IHC |
| Working dilutions | Optimal dilution should be determined by the end user. The following instructions are only guidelines: FC: 1:10-1:1000 IHC: 1:10-1:500 |
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