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Transcription factor E2F1 acetyl-lysine 120 and 125 (E2F-1) antibody
PBR3
PRB-binding protein E2F-1
Retinoblastoma-associated protein 1 (RBAP-1)
Retinoblastoma-binding protein 3 (RBBP-3)
Gene name: E2F1, RBBP3
PRB-binding protein E2F-1
Retinoblastoma-associated protein 1 (RBAP-1)
Retinoblastoma-binding protein 3 (RBBP-3)
Gene name: E2F1, RBBP3
As low as
$323.40
In stock
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00013935
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis.
| ID Covalab | pab0726-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from internal domain of human E2F-1 protein containing acetyl lysine 120 and 125 |
| Activity cross reaction | Reacts with human E2F-1 acK120 and acK125. May cross-react with E2F-1 from mouse and other species due to sequence homology |
| Species | Hu, Ms |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Transcription factor E2F1 acetyl-lysine 120 and 125 (E2F-1) |
| Uniprot ID | Q01094 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: IHC-P (10 µg/ ml) |
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