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CD172a antibody (15-414)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1, SHPS-1)
Gene name: SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Gene name: SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
As low as
$448.50
In stock
Ref
00118513
CD172a, the signal-regulatory protein alpha (SIRP alpha), also known as SH2 domain-containing phosphatase substrate-1 (SHPS1), is a 75-110 kDa transmembrane glycoprotein expressed mainly on granulocytes, monocytes, macrophages, dendritic cells and neurons. Its extracellular ligand is CD47. CD172a serves as a substrate of activated receptor tyrosine kinases and upon phosphorylation it recruits SH2 domain-containing tyrosine phosphatases, thereby regulating signal transduction processes related to cell activation, transmigration and phagocytosis. CD172a is a specific marker of cardiomyocytes derived from human pluripotent stem cells and serves as a negative regulator of signaling and growth in myeloid progenitor cells.
| ID Covalab | mab21286 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 15-414 |
| Isotype | IgG2a |
| Raised in | Mouse |
| Immunogen | The mouse monoclonal antibody 15-414 recognizes en extracellular epitope of CD172a (SIRP alpha), an approximately 90 kDa transmembrane glycoprotein expressed on cells of myeloid origin and neurons. |
| Activity cross reaction | Kg-1a cell line |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | NaN3 15 mM |
| Storage instructions | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label. |
| Target | CD172a |
| Uniprot ID | P78324 |
| Gene ID | 140885 |
| Applications | FC |
| Working dilutions | Optimal dilution should be determined by the end user. |
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