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Prostaglandin D2 receptor 2 (PTGDR2) antibody (BM16)
Prostaglandin D2 receptor 2
Chemoattractant receptor-homologous molecule expressed on Th2 cells
G-protein coupled receptor 44
CD294
Gene name: PTGDR2, CRTH2, DL1R, GPR44
Chemoattractant receptor-homologous molecule expressed on Th2 cells
G-protein coupled receptor 44
CD294
Gene name: PTGDR2, CRTH2, DL1R, GPR44
As low as
€407.80
In stock
Ref
00122087
CD294 (prostaglandin D2 receptor 2) is a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells, but also on eosinophils and basophils. It mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of CD294 gene have been associated with asthma susceptibility. Outside the immune system CD294 is expressed e.g. in gut, heart, and brain. The intracellular C terminal tail contains sites for phosphorylation by protein kinase C.
ID Covalab | mab21339 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | BM16 |
Isotype | IgG2a |
Raised in | Rat |
Immunogen | The rat monoclonal antibody BM16 recognizes an extracellular epitope of CD294 / CRTH2 (prostaglandin D2 receptor 2), a G-protein-coupled seven-transmembrane protein expressed on Th2 cells, peripheral blood basophils and eosinophils. |
Species | Hu |
Labelling | None |
Form | Purified (protein G) |
Preservative | NaN3 15 mM |
Storage instructions | Store at 2-8°C. Do not freeze. |
Target | CD294 |
Uniprot ID | Q9Y5Y4 |
Gene ID | 11251 |
Applications | FC |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : FC (1-4 µg/ml) |
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