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CD272 antibody (MIH26)
B- and T-lymphocyte attenuator
B- and T-lymphocyte-associated protein
CD272
Gene name: BTLA
B- and T-lymphocyte-associated protein
CD272
Gene name: BTLA
As low as
€407.80
In stock
Ref
00119458
CD272, a type I transmembrane glycoprotein, contains in its intracellular domain two ITIM sequences, which are upon CD272 triggering phosphorylated and recruit SHP phosphatases to attenuate cell activation. CD272 is expressed on B and T lymphocytes, NK cells, dendritic cells, and macrophages, and its ligand is CD270. Defects in CD272-CD270 inhibitory mechanism lead to autoimmune diseases. Overexpression of CD272 is a marker of tolerant T cells.
ID Covalab | mab21326 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | MIH26 |
Isotype | IgG2a kappa |
Raised in | Mouse |
Immunogen | The mouse monoclonal antibody MIH26 recognizes an extracellular epitope of CD272, a transmembrane glycoprotein serving as a negative regulator of the activation in various leukocyte types. |
Species | Hu |
Labelling | None |
Form | Purified (protein A) |
Preservative | NaN3 15 mM |
Storage instructions | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label. |
Target | BTLA |
Uniprot ID | Q7Z6A9 |
Applications | FC |
Working dilutions | Optimal dilution should be determined by the end user. FC (2-5 µg/ml) |
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