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CD46 / Membrane cofactor protein antibody (3F1)
TLX
Trophoblast leukocyte common antigen
CD46
Gene name : CD46, MCP, MIC10
Trophoblast leukocyte common antigen
CD46
Gene name : CD46, MCP, MIC10
As low as
€253.00
In stock
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00012930
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
ID Covalab | mab0073-P |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | 3F1 |
Isotype | IgG1 / Kappa |
Raised in | Mouse |
Immunogen | Recombinant CD46 protein |
Activity cross reaction | Reacts with human 44 kDa CD46 protein. Diffuse and duplicated bands can be seen due to the glycosylation of CD46. |
Species | Hu |
Labelling | None |
Form | Purified (protein A) |
Preservative | None |
Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
Target | CD46 / Membrane cofactor protein |
Uniprot ID | P15529 |
Gene ID | 4179 |
Applications | ELISA, FC, IHC - P, WB |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ELISA 1:20 000 - 1:100 000 IHC-P 10 µg/ml WB 1:2000 - 1:10000 |
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