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ADAM17 (aa807-823) antibody

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17)
Snake venom-like protease
TNF-alpha convertase
TNF-alpha-converting enzyme
ADAM18, MGC71942, Tumor necrosis factor alpha converting enzyme
Gene name : ADAM17, CSVP, TACE
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway

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Ref : 00015637

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Product Code pab70244
Immunogen Synthetic peptide from human ADAM17.
Target Specificity Reacts with human TACE. Cross reacts with mouse and rat protein.
Name ADAM17
Accession Number P78536
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.02%
Storage +4°C or -20°C, Avoid repeated freezing and thawing.
Applications Western Blot, IHC - Paraffin sections
Working dilutions IHC - P (20 µg/ml), WB
Research areas Cytoskeleton,Immunology,Signal transduction
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IHC : ADAM17 (aa807-823) antibody<br/>(pab70244)<br/>Anti-ADAM17 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 µg/ml.

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