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EB2 pS222 antibody
Microtubule-associated protein RP/EB family member 2
APC-binding protein EB2
End-binding protein 2, EB2
Gene name: Mapre2
APC-binding protein EB2
End-binding protein 2, EB2
Gene name: Mapre2
As low as
€543.30
In stock
Ref
00117741
EB2 S222 site is a target for phosphorylation by the CDKL5 protein kinase; loss-of-function mutations in the human CDKL5 gene are associated with CDKL5 Deficiency Disorder, a neurodevelopmental disorder with intractable epilepsy (Baltussen, Negraes, et al. (2018). EMBO J. 37: e99763).
| ID Covalab | pab01032-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic phospho-peptide surrounding Serine 222 from mouse EB2 |
| Activity cross reaction | Reacts with mouse EB2 phospho Serine 222. |
| Species | Ms |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | EB2 pS222 |
| Uniprot ID | Q8R001 |
| Applications | ELISA, ICC, IF, WB |
| Working dilutions | Optimal dilution should be determined by the end user. |
| Publication | * Colarusso A et al. Active human full-length CDKL5 produced in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125. Microb Cell Fact, Oct 2022 * Van Bergen NJ et al. Abnormalities of mitochondrial dynamics and bioenergetics in neuronal cells from CDKL5 deficiency disorder, Neurobiology of Disease, 24 April 2021 * Baltussen LL et al. EMBO J. 2018 Sep 28. pii: e99763. |
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