Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase
|Product type||Primary antibodies|
|Immunogen||Synthetic peptide derived from C terminal part of Xenopus tropicalis ARPP-19 containing a phosphoserine 109|
|Activity cross reaction||Reacts with Xenopus tropicalis ARPP-19 pS109|
|Form||Antigen affinity purified|
|Storage instructions||Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
|Working dilutions||Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB 1:500 - 1:5000
|Publication||Dupré A. Phosphorylation of ARPP19 by protein kinase A prevents meiosis resumption in Xenopus oocytes. Nat Commun. 2014 Feb 14,5:3318.|
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