ARPP-19 pS109 antibody

cAMP-regulated phosphoprotein 19
Gene name : arpp19
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Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase
More Information
ID Covalab pab0966-IP
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide derived from C terminal part of Xenopus tropicalis ARPP-19 containing a phosphoserine 109
Activity cross reaction Reacts with Xenopus tropicalis ARPP-19 pS109
Species Xe
Labelling None
Form Antigen affinity purified
Preservative None
Storage instructions Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target ARPP-19 pS109
Uniprot ID Q28GU6
Gene ID 447957
Applications ELISA, WB
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB 1:500 - 1:5000
Publication Dupré A. Phosphorylation of ARPP19 by protein kinase A prevents meiosis resumption in Xenopus oocytes. Nat Commun. 2014 Feb 14,5:3318.
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