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CRMP-2 pY479 antibody
Dihydropyrimidinase-related protein 2 (DRP-2)
N2A3
Unc-33-like phosphoprotein 2 (ULIP-2)
Gene name : DPYSL2, CRMP2, ULIP2
N2A3
Unc-33-like phosphoprotein 2 (ULIP-2)
Gene name : DPYSL2, CRMP2, ULIP2
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00102106
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
| ID Covalab | pab0479-IP |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from C-terminal domain containing phospho-tyrosine 479 (pY479) of human CRMP-2 |
| Activity cross reaction | Reacts with CRMP-2 pY479 from human, rat and mouse. No cross reactivity was detected with CRMP1, CRMP3, CRMP4 or CRMP5 |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Store at -20°C Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Collapsin response mediator protein 2 (CRMP-2) |
| Uniprot ID | Q16555 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - IHC : 1/50 to 1/200 - WB : 1/100 to 1/1 000 |
| Publication | Varrin-Doyer M et al. Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. J Biol Chem. 2009 May 8:284(19):13265-76. |
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