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Kos1 antibody
Non-receptor tyrosine-protein kinase TNK1
Kinase of embryonic stem cells
Gene name: Tnk1, Kos1
Kinase of embryonic stem cells
Gene name: Tnk1, Kos1
As low as
€480.40
In stock
Ref
00099461
Kinase of embryonic stem cells (Kos1) is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
| ID Covalab | pab51805 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | C-terminal residues 421-434 [QNQVQSLPAGSAEP] of the 47 kDa mouse Kos1 / Tnk1 protein. |
| Activity cross reaction | Reacts with mouse and human Kos1. |
| Species | Hu, Ms |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Kos1 |
| Uniprot ID | Q99ML2 |
| Applications | ICC, IF, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ICC/IF (1:50 - 1:200) WB (1:500 - 1:1000) |
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