Smac (C-Terminus) antibody

As low as €671.00
In stock
Inhibitors of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases has been identified and designated Smac/DIABLO. Smac is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates the cytochrome c/Apaf-1/caspase-9 pathway. The N-terminal amino acids of Smac are required for binding to IAPs and for activation of caspases. Smac is expressed in a variety of human and mouse tissues.
More Information
ID Covalab pab60301
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide corresponding to the C-terminus part of (aa 225-239) of human Smac (accession no. AAF87716)
Activity cross reaction Reacts with human, mouse and rat Smac.
Species Hu, Ms, Rat
Labelling None
Form Purified
Preservative NaN3 0.02%
Storage instructions Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
Target Smac
Applications IHC, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
WB (1 µg/ml)
IHC (5µg/ml)
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