Park7/DJ-1 is one of several genes thought to cause autosomal-recessive early-onset parkinsonism. Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death.
|Product type||Primary antibodies|
|Immunogen||Synthetic peptide corresponding to amino acids 167-189 (AIVEALNGKEVAAQVKAPLVLKD) of human PARK7 conjugated to KLH at the N-terminus.|
|Activity cross reaction||Reacts with human and mouse PARK7. Sequence homology to mouse and rat DJ-1 is 82%.|
|Storage instructions||Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 months from date of receipt.
|Working dilutions||Optimal dilution should be determined by the end user.
The following are guidelines only :
|Positive control||HEK293 cell lysate or mouse brain tissue lysate|
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