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DR5 antibody
Tumor necrosis factor receptor superfamily member 10B
Death receptor 5
TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2
CD_antigen: CD262
KILLER/DR5,TRICK2A, TRICK2B, TRICKB
Gene name: TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Death receptor 5
TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2
CD_antigen: CD262
KILLER/DR5,TRICK2A, TRICK2B, TRICKB
Gene name: TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
As low as
€671.00
In stock
Ref
00097828
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain-containing receptors. TRAIL/Apo2L is a new member of the TNF family. A novel death domain containing receptor for TRAIL was recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several independent laboratories. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.
| ID Covalab | pab60122 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide corresponding to aa 388- 407 of human DR5 precursor (accession no.AF012535) |
| Activity cross reaction | Reacts with human and mouse DR5. |
| Species | Hu, Ms |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.02% |
| Storage instructions | This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | DR5 |
| Uniprot ID | O14763 |
| Gene ID | 8795 |
| Applications | ICC, IF, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB (2 µg/ml) ICC (5 µg/ml) |
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