ASK1 (C-Terminus) antibody

Mitogen-activated protein kinase kinase kinase 5
Apoptosis signal-regulating kinase 1, ASK-1
MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5
Gene name: MAP3K5, ASK1, MAPKKK5, MEKK5
As low as €671.00
In stock
A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-jun N-terminal kinase (JNK) and p36 MAP kinase. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induces apoptotic cell death. A catalytically inactive form of ASK1 inhibits TNF -induced apoptosis. ASK1 is expressed in a variety of human and mouse tissues.
More Information
ID Covalab pab60029
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide corresponding to aa 1356-1375 of human ASK1. This peptide sequence is different from that of mouse in the last two amino acids
Activity cross reaction Reacts with human ASK1.
Species Hu
Labelling None
Form Purified
Preservative NaN3 0.02%
Storage instructions Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
Target ASK1
Uniprot ID Q99683
Gene ID 4217
Applications ICC, IF, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
WB (0.5 - 1 µg/ml)
ICC (10 µg/ml)
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