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ASK1 (C-Terminus) antibody
Mitogen-activated protein kinase kinase kinase 5
Apoptosis signal-regulating kinase 1, ASK-1
MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5
Gene name: MAP3K5, ASK1, MAPKKK5, MEKK5
Apoptosis signal-regulating kinase 1, ASK-1
MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5
Gene name: MAP3K5, ASK1, MAPKKK5, MEKK5
As low as
€671.00
In stock
Ref
00097735
A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-jun N-terminal kinase (JNK) and p36 MAP kinase. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induces apoptotic cell death. A catalytically inactive form of ASK1 inhibits TNF -induced apoptosis. ASK1 is expressed in a variety of human and mouse tissues.
| ID Covalab | pab60029 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide corresponding to aa 1356-1375 of human ASK1. This peptide sequence is different from that of mouse in the last two amino acids |
| Activity cross reaction | Reacts with human ASK1. |
| Species | Hu |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | ASK1 |
| Uniprot ID | Q99683 |
| Gene ID | 4217 |
| Applications | ICC, IF, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB (0.5 - 1 µg/ml) ICC (10 µg/ml) |
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