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Bcl-3 (150-3.5) antibody
B-cell lymphoma 3 protein homolog, BCL-3
Gene name: Bcl3
Gene name: Bcl3
As low as
€520.00
In stock
Ref
00096551
The gene encoding Bcl-3 was first identified as the gene altered in some cases of chronic B cell lymphocytic leukemia and was later found to belong to the IκB subfamily of inhibitors of NFκB transcription factors. Bcl-3 does not have DNA-binding activity, but it interacts with NFκB1 and NFκB2 which, when bound to DNA, repress gene transcription. Therefore, Bcl-3 may promote gene expression that is repressed by members of the NFκB family. Bcl-3 RNA is highly expressed in spleen and liver with lower levels of expression in heart, skeletal muscle, lung, kidney, and testes.
| ID Covalab | mab60038 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 150-3.5 |
| Isotype | IgG1 / Lambda |
| Raised in | Hamster |
| Immunogen | Recombinant mouse Bcl-3-6His. |
| Activity cross reaction | Reacts with human and mouse Bcl-3. |
| Species | Hu, Ms |
| Labelling | None |
| Form | Purified |
| Preservative | None |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | Bcl-3 |
| Uniprot ID | Q9Z2F6 |
| Applications | ELISA, FC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB 2 µg/ml. |
| Publication | Bassetti MF et al Transgenic Bcl-3 slows T cell proliferation. Int Immunol. 2009 Apr,21(4):339-48. |
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