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Amyloid Beta 1-40 (Ab40.1) antibody
Amyloid beta A4 protein
ABPP
APPI, APP
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
PreA4
Protease nexin-II, PN-II
Beta-amyloid protein 40
Beta-APP40
Gene name: APP, A4, AD1
ABPP
APPI, APP
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
PreA4
Protease nexin-II, PN-II
Beta-amyloid protein 40
Beta-APP40
Gene name: APP, A4, AD1
As low as
€623.00
In stock
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00096542
Accumulation and aggregation of amyloid β (Aβ) in the brain is indicated as the trigger of a pathological cascade that causes Alzheimer disease (AD). The highly amyloidogenic 42-amino acid form of Aβ (Aβ42) and amino-terminally truncated forms of Aβ (Aβx-42) are the predominant species of Aβ typically found in diffuse and senile plaques within the AD brain. There is a strong correlation between Aβ40 positivity and mature plaques. In the AD cortex, diffuse plaques, representing the earliest stage of Aβ deposition, are positive for Aβ42, but negative for Aβ40.
| ID Covalab | mab60029 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | Ab40.1 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Synthetic peptide corresponding to Aβ35-40. |
| Activity cross reaction | Reacts with human and mouse Aβx-40 |
| Species | Hu, Ms |
| Labelling | None |
| Form | Purified |
| Preservative | None |
| Storage instructions | Stable for at least one year at -20°C |
| Target | Amyloid Beta 1-40 |
| Uniprot ID | P05067 |
| Gene ID | 351 |
| Applications | ELISA, IF, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: 1 - 10 µg/ml for any application |
| Publication | * Levites Y et al. Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. FASEB J. 2006 Dec:20(14):2576-8. * Levites Y et al. Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. J Neurosci. 2006 Nov15:26(46):11923-8. * Levites Y et al. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest. 2006 Jan:116(1):193-201. |
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