Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.
|Synthetic peptide derived from N terminal region of Sprouty homolog 4 (Spry-4)
|Activity cross reaction
|Reacts with human 32 kDa Spry-4 protein. Cross reacts with mouse, bovine and chicken. Not tested on other species.
|Antigen affinity purified
|Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt
|Sprouty homolog 4 (Spry-4)
|Antibody / Antigen
|ELISA, IHC, WB
|Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/100 to 1/500
- WB : 1/500 to 1/2 000
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