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Nkx6.1 antibody
Homeobox protein Nkx-6.1
Homeobox protein NK-6 homolog A
Gene name: NKX6-1, NKX6A
Homeobox protein NK-6 homolog A
Gene name: NKX6-1, NKX6A
As low as
€436.70
In stock
Ref
00096435
NKX6.1 is a bi-functional transcription factor that has effects in both the central nervous system and in the pancreas. It has both expression and repression effects on genes, leading to the proper formation of motoneurons, oligodendrocytes, and insulin-secreting beta cells. It is known to interact with Pax6 and Pdx-1, probably at or near the 60 amino acid homeobox DNA-binding domain.Due to its obvious relationship to beta cells and CNS, NKX6.1 is becoming a more interesting target for therapies in diabetes and certain brain diseases.
| ID Covalab | pab52747 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | A genomic peptide made to an internal region of the human Nkx6.1 protein (within residues 50-200). [Swiss-Prot P78426] |
| Activity cross reaction | Reacts with human and mouse Nkx6.1. |
| Species | Hu, Ms |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.05% |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Nkx6.1 |
| Uniprot ID | P78426 |
| Applications | ICC, IF, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: - IHC - P : 1/50 to 1/100 - WB: 1:100-1:2000 |
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