SIRT1 (Internal) antibody

NAD-dependent protein deacetylase sirtuin-1, hSIRT1
Regulatory protein SIR2 homolog 1
SIR2-like protein 1, hSIR2
SirtT1 75 kDa fragment, 75SirT1
Gene name: SIRT1, SIR2L1
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00038340
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression.
More Information
ID Covalab pab75638
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Goat
Immunogen Synthetic peptide C-EKPQEVQTSRNVES from an internal region of human SIRT1 (NP_036370.2; NP_001135970.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse (93%); Rat (86%).
Activity cross reaction Reacts with SIRT1 from human, gorilla, gibbon, monkey and marmoset. This antibody is expected to recognize both reported isoforms (NP_036370.2; NP_001135970.1).
Species Hu, Mk
Labelling None
Form Antigen affinity purified
Preservative 0.02% NaN3
Storage instructions Store at -20°C. Minimize freezing and thawing.
Target SIRT1
Uniprot ID Q96EB6
Gene ID 23411
Applications ELISA, IHC - P, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA (1:64000),
IHC-P (3.75 µg/ml),
WB (0.05 - 0.2 µg/ml)
Positive control Jurkat cell
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