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SIRT1 (Internal) antibody
NAD-dependent protein deacetylase sirtuin-1, hSIRT1
Regulatory protein SIR2 homolog 1
SIR2-like protein 1, hSIR2
SirtT1 75 kDa fragment, 75SirT1
Gene name: SIRT1, SIR2L1
Regulatory protein SIR2 homolog 1
SIR2-like protein 1, hSIR2
SirtT1 75 kDa fragment, 75SirT1
Gene name: SIRT1, SIR2L1
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00038340
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression.
| ID Covalab | pab75638 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Goat |
| Immunogen | Synthetic peptide C-EKPQEVQTSRNVES from an internal region of human SIRT1 (NP_036370.2; NP_001135970.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse (93%); Rat (86%). |
| Activity cross reaction | Reacts with SIRT1 from human, gorilla, gibbon, monkey and marmoset. This antibody is expected to recognize both reported isoforms (NP_036370.2; NP_001135970.1). |
| Species | Hu, Mk |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | 0.02% NaN3 |
| Storage instructions | Store at -20°C. Minimize freezing and thawing. |
| Target | SIRT1 |
| Uniprot ID | Q96EB6 |
| Gene ID | 23411 |
| Applications | ELISA, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ELISA (1:64000), IHC-P (3.75 µg/ml), WB (0.05 - 0.2 µg/ml) |
| Positive control | Jurkat cell |
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