Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
|Product type||Primary antibodies|
|Isotype||IgG2b / Kappa|
|Immunogen||Recombinant p53 protein|
|Activity cross reaction||Reacts with wild type and mutant p53, the epitope is within residues 18-30 of human p53|
|Storage instructions||Stable at +2-8°C for 12 months
For longer storage, freeze aliquots
Antibodies are guaranteed for 6 months from date of receipt.
|Working dilutions||Optimal dilutions should be determined by the end user.|
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