Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
|IgG2a / Kappa
|Recombinant human protein purified from E. coli (His-Bcl-2).
|Activity cross reaction
|Reacts with human BCL2 / Bcl-2.
|Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
|Apoptosis regulator Bcl-2
|ELISA, IHC - P, IP, WB
|ELISA, IHC-P (1:100), IP, WB (1:2000)
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