p53 antibody (BP53-12)

Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
Out of stock
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription
More Information
ID Covalab mab70600
Product type Primary antibodies
Clonality Monoclonal antibody
Clone BP53-12
Isotype IgG2a / Kappa
Raised in Mouse
Immunogen Recombinant human p53.
Activity cross reaction Reacts with human TP53 / p53. Hybridoma: Produced by the fusion between BALB/c mouse splenocytes and mouse myeloma P3-X63/AG8.653 cells using conventional hybridoma technology.
Species Hu
Labelling None
Form Purified (protein A)
Preservative 0.01% NaN3
Storage instructions +4°C or -20°C, Avoid repeated freezing and thawing.
Target p53
Uniprot ID P04637
Gene ID 7157
Applications ELISA, ICC, IF, IHC - P, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA (1:2000 - 1:10000), IHC - P (2.5 µg/ml), IP, WB (1:500 - 1:2000)
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