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Human fibrinogen is a complex ~340kD hetero-hexameric (di-trimeric) glycoprotein consisting of 3 pairs of alpha, beta and gamma chains linked by a series of 29 disulphide bonds. The six chains are arranged in such a way that all the N-Terminal ends adjoin to form a central with two trimeric coiled coil structures connecting to outer D domains. Fibrinogen plays an important role in the coagulation process with the D and E domains interacting via the C-Terminal ends of the alpha chains during fibrin clot cross-linking.
ID Covalab | pab74558 |
---|---|
Product type | Primary antibodies |
Clonality | Polyclonal antibody |
Isotype | IgG |
Raised in | Sheep |
Immunogen | Human Fibrinogen purified from plasma. |
Activity cross reaction | Reacts with human Fibrinogen. Cross reacts with mouse and rat protein. This antibody shows minimal cross-reactivity with related serum proteins |
Species | Hu, Ms, Rat |
Labelling | None |
Form | Purified (protein G) |
Preservative | NaN3 0.09% |
Storage instructions | +4°C or -20°C, Avoid repeated freezing and thawing. Store undiluted. |
Target | Fibrinogen |
Applications | ELISA, IF, IHC - F, IHC - P |
Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: ELISA (1:50 - 1:100), IHC-P (5 µg/ml) |
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