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GRP78 / HSPA5 (aa550-600) antibody
78 kDa glucose-regulated protein, GRP-78
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein, BiP
Gene name: HSPA5, GRP78
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein, BiP
Gene name: HSPA5, GRP78
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Categorized as stress response proteins, BiPs play an important role in folding and assembly of nascent proteins and in scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5- nontranslated region of BiP mRNA. BiP IRES activity increases when cells are heat-stressed. GRP78 is also important in maintenance of cell homeostasis and the prevention of apoptosis. Levels of GRP78 protein are reduced in brains of Alzheimer’s disease patients.
| ID Covalab | pab74511 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Isotype | IgG |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide from aa550-600 of human HSPA5 / GRP78. |
| Activity cross reaction | Reacts with human HSPA5 / GRP78. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | NaN3 0.05% |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Target | HSPA5 / GRP78 |
| Uniprot ID | P11021 |
| Gene ID | 3309 |
| Applications | IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IHC-P (10 µg/ml), WB (1 - 3 µg/ml) |
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