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A2M / Alpha-2-Macroglobulin (C-Terminus) antibody
Alpha-2-macroglobulin (Alpha-2-M)
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
A2M, CPAMD5, DKFZp779B086, FWP007, S863-7
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
A2M, CPAMD5, DKFZp779B086, FWP007, S863-7
Out of stock
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00020312
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
| ID Covalab | pab72635 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide from human A2M / Alpha-2-Macroglobulin. |
| Activity cross reaction | Reacts with the C-terminus part of human A2M / Alpha-2-Macroglobulin. Cross reacts with rat protein. |
| Species | Hu, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.01% |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Target | A2M / Alpha-2-Macroglobulin |
| Accession Number | P01023 |
| Applications | ELISA, IHC - P, WB |
| Working dilutions | ELISA, IHC-P (10 µg/ml), WB (1 µg/ml) |
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