AIRE (Internal) antibody

Autoimmune regulator
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein (APECED protein)
AIRE, AIRE1, APECED, Apeced protein, APS1, APSI, PGA1
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00019415
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes
More Information
ID Covalab pab72142
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Goat
Immunogen Synthetic peptide C-KDVDLSQPRKGRKP from an internal region of human AIRE (NP_000374.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Rat (100%), Horse (100%), Dog (100%), Hamster (100%), Elephant (100%)
Activity cross reaction Reacts with human AIRE. This antibody is expected to recognise isoform 1 (NP_000374.1) only. Cross reacts with bovine, canine and rat protein.
Species Bov, Ca, Hu, Rat
Labelling None
Form Antigen affinity purified
Preservative NaN3 0.02%
Storage instructions Store at -20°C. Minimize freezing and thawing.
Target AIRE
Accession Number O43918
Applications ELISA, IHC - P, WB
Working dilutions ELISA (1:32000), IHC-P (2.5 µg/ml), WB (0.5 - 1 µg/ml)
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