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AIRE (C-Terminus) antibody
Autoimmune regulator
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein (APECED protein)
AIRE, AIRE1, APECED, Apeced protein, APS1, APSI, PGA1
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein (APECED protein)
AIRE, AIRE1, APECED, Apeced protein, APS1, APSI, PGA1
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00019414
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes.
| ID Covalab | pab72141 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Goat |
| Immunogen | Synthetic peptide C-QSMARPAAPFPS from the C-terminus of human AIRE (NP_000374.1, NP_000649.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%). |
| Activity cross reaction | Reacts with human AIRE. This antibody is expected to recognize isoforms 1 and 2 (NP_000374.1 and NP_000649.1 respecively). |
| Species | Hu |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Store at -20°C. Minimize freezing and thawing. |
| Target | AIRE |
| Accession Number | O43918 |
| Applications | ELISA, IHC - P, RIA |
| Working dilutions | ELISA (1:32000), IHC-P (2.5 µg/ml), RIA (0.01 - 0.03 µg/ml) |
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