Tetratricopeptide repeat protein 3 (TTC3/TPRD) antibody

Protein DCRR1
RING finger protein 105
TPR repeat protein D
Tetratricopeptide repeat protein 3, TPR repeat protein 3
Gene name: TTC3, DCRR1, RNF105, TPRD
As low as €278.30
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00014653
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
More Information
ID Covalab pab0532
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide derived from Cter domain of human TTC3
Activity cross reaction Reacts with human E3 ubiquitin-protein ligase TTC3
Species Hu
Labelling None
Form Antiserum
Preservative None
Storage instructions Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target E3 ubiquitin-protein ligase TTC3
Uniprot ID P53804
Applications ELISA, IF, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
IF (1:100 - 1:500)
WB (1:500 - 1:5000)
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