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CRMP-2 antibody
Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response
mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like
phosphoprotein 2) (ULIP-2) [DPYSL2]
Dihydropyrimidinase-related protein 2 (DRP-2)
N2A3
Unc-33-like phosphoprotein 2 (ULIP-2)
Gene name: DPYSL2, CRMP2, ULIP2
mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like
phosphoprotein 2) (ULIP-2) [DPYSL2]
Dihydropyrimidinase-related protein 2 (DRP-2)
N2A3
Unc-33-like phosphoprotein 2 (ULIP-2)
Gene name: DPYSL2, CRMP2, ULIP2
As low as
€278.30
In stock
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00013398
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
| ID Covalab | pab0115 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator |
| Activity cross reaction | Reacts with human 65 kDa CRMP-2. Cross reacts with mouse and rat proteins. Do not react with CRMP-1, CRMP-3, CRMP-4 or CRMP-5. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Antiserum |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Collapsing-response mediator protein 2 (CRMP-2) |
| Uniprot ID | Q16555 |
| Gene ID | 1808 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : -IHC : 1/500 - WB :1/2 000 |
| Publication | -Greene N.D. et al. Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. Proteomics. 2007 Apr;7(8):1336-44. - Veyrac A. et al. Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system. Eur J Neurosci. 2005;21:2635-48. -Bertin S. et al. Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol. 2005;486:1-17. - Quach T. et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol Cell Neurosci. 2004;25:433-43. - Charrier E. et al. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol Neurobiol. 2003;28:51-64. Review. - Ricard D et al. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. J Neurosci. 2001 ; 21:7203-14. - Honnorat J. et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur J Neurosci. 1999;11:4226-32. |
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