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Heparanase (HPSE) antibody
Endo-glucoronidase
Heparanase-1 (Hpa1)
Gene name : HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1
Heparanase-1 (Hpa1)
Gene name : HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1
As low as
€294.00
In stock
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00013374
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Highly selective enzyme cleaving HSPGs at specific intrachain sites. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation.
| ID Covalab | pab0232-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from human N terminal region of Heparanase (HPSE) |
| Activity cross reaction | Reacts with human 62 kDa HPSE protein, Heparanase 50 kDa subunit and Heparanase 8 kDa subunit. Cross reacts with mouse, rat and bovine protein due to sequence homology. |
| Species | Hu, Rat |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Heparanase (HPSE) |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - IHC : 1/100 to 1/500 - WB : 1/500 to 1/2 000 |
| Publication | - Navarro F.P. et al. Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats. J Neurochem. 2008 Apr;105(1):34-45. |
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