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p53 antibody (H53C2)
Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
As low as
€278.30
In stock
Ref
00012795
Belongs to the p53 family.
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.
| ID Covalab | mab0052-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | H53C2 |
| Isotype | IgG1 / Kappa |
| Raised in | Mouse |
| Immunogen | Recombinant 6-histidine-troncated p53(6H-Cp53) |
| Activity cross reaction | Reacts with human truncated p53 from MCF7 cells and endogenous p53 from various tumour cells. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Cellular tumor antigen p53 |
| Uniprot ID | P04637 |
| Gene ID | 7157 |
| Applications | ELISA, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IHC (1:100 - 1:500) IP (1:50 - 1:200) WB (1:200 - 1:1000) |
| Publication | * Voeltzel T. et al. A new set of monoclonal antibodies directed to proline-rich and central regions of p53.Hybrid Hybridomics. 2004 Oct:23(5):287-92. |
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