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Angiotensinogen antibody
Angiotensinogen
Serpin A8
Gene name: AGT, SERPINA8
Serpin A8
Gene name: AGT, SERPINA8
As low as
€294.00
In stock
Ref
00011277
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.
| ID Covalab | pab0624-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from Nter domain of human Serpin A8 protein |
| Activity cross reaction | Reacts with human 53 kDa AGT protein. Cross reacts with the proteins from mouse, rat and other species due to sequence homology. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Angiotensinogen (AGT) |
| Uniprot ID | P01019 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user The following are guidelines only : - IHC : 1/50 to 1/500 - WB : 1/200 to 1/2 000 |
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