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Anti-Mouse Alpha Synuclein Mouse Antibody
Alpha Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, PARK1, PARK 1, alphaSYN, PARK 4, PARK4, Parkinson disease familial 1, Parkinson disease (autosomal dominant, Lewy body) 4, SYN
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€573.00
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00123916
Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4).
SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
| ID Covalab | mab60839 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 3F8 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Mouse alpha synuclein aggregate |
| Activity cross reaction | Binds within the 101-140 aa region of human alpha synuclein, determined using WB and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Does not detect truncated alpha Synuclein (aa 1-114) |
| Species | Human, Mouse, Rat |
| Form | Purified |
| Preservative | 0.09% Sodium azide |
| Storage instructions | This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | Alpha Synuclein |
| Uniprot ID | O55042 |
| Gene ID | 20617 |
| Applications | DB, ELISA, ICC/IF, IHC, WB |
| Working dilutions | WB (1:1000); DB (1:1000); IHC (1:200); ICC/IF (1:100); ELISA (1:1000); optimal dilutions for assays should be determined by the user. |
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