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Anti-4-Hydroxynonenal Mouse Antibody
4-Hydroxynonenal, 4-Hydroxy Nonenal (4-HNE), 4-Hydroxy Nonenal, 4-HNE, 4-hydroxy Hexenal, HNE, 4-hydroxy-2-nonenal
As low as
€731.00
In stock
Ref
00123902
4-Hydroxy-2-nonenol (4-HNE) is an unsaturated aldehyde derived from lipid peroxidation. 4-HNE is an electrophile and reacts with protein nucleophiles such as cysteine, histine, and lysine (1). Low levels of 4-HNE promote cell survival via cellular antioxidant induction whereas higher levels lead to autophagy, apoptosis, and ultimately necrosis. 4-HNE has been linked to Alzheimer's disease, Parkinson's disease, cancer, cardiovascular diseases, diabetes, and liver disease.
| ID Covalab | mab60825 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 12F7 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Synthetic 4-Hydroxynonenal modified Keyhole Limpet Hemocyanin (KLH). |
| Activity cross reaction | Specific for 4-Hydroxynonenal (4-HNE) modified proteins. Does not detect free 4-Hydroxynonenal. Does not cross-react with 4-Hydroxy-2-hexenal, Acrolein, Crotonaldehyde, Hexanoyl Lysine, Malondialdehyde, or Methylglyoxal modified proteins. |
| Species | Species Independent |
| Form | Purified |
| Preservative | 0.09% Sodium azide |
| Storage instructions | This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | 4-Hydroxynonenal |
| Applications | ELISA, ICC/IF, WB |
| Working dilutions | WB (1:1000); ICC/IF (1:50); ELISA (1:1000); optimal dilutions for assays should be determined by the user. |
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