We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Anti-Estrogen Receptor beta Antibody
ER-beta, Nuclear receptor subfamily 3 group A member 2
As low as
€667.00
In stock
Ref
00123639
Anti-Estrogen Receptor beta Antibody
| ID Covalab | mab60674 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 6A12 |
| Isotype | IgG2b |
| Raised in | Mouse |
| Immunogen | 6-His fusion protein containing the region encoding aa 1-153 of human estrogen receptor-b (ER-b) expressed in E. coli. |
| Activity cross reaction | This antibody recognizes human ER-b, a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER-b are very similar to ER-alpha with the ligand and DNA binding domains being highly conserved. The N-terminus of each receptor, which serves as their transactivation domain, are significantly different. Like ER-alpha, ER-b binds to estrogen with a high affinity and regulates estrogen-specific gene activation through direct interaction with estrogen response elements. |
| Species | Human |
| Form | Purified |
| Storage instructions | This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze- thaw cycles. |
| Target | Estrogen Receptor beta |
| Uniprot ID | Q92731 |
| Gene ID | 2100 |
| Applications | ChIP, ICC/IF, IHC, WB |
| Working dilutions | Immunoblotting: use at 1-5 ug/mL. Positive controls: Native receptor from human thymus, spleen, ovary, and testis or recombinant protein. |
Write Your Own Review